Environmental Oncology 101
Categories of Environmental Exposures
| Four basic categories of environmental exposures exist - chemical, biologic, physical, and social. The first three agents are definable more readily than the fourth, but the importance of social factors on health has become a focus of academic interest and public-policy development in recent years.
Chemical agents include air pollutants (sulfur dioxide, nitrogen dioxide, ozone, mercury, and others), toxic waste, pesticides, volatile organic compounds, and metals like lead and chromium. Biologic agents include infectious organisms present in food and water and insect or animal allergens (pet dander, dust mite excrement). Physical agents include ionizing radiation (x-rays, radon, nuclear fallout), non-ionizing radiation (sunlight), and noise. Social factors are not as tangible or definable as chemical, biologic, or physical agents but are nonetheless important. Socioeconomic status, including income and place of residence, safety, and access to adequate health care affect overall health and the development of environmentally related disease. |
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| Carriers | ||
| For an agent – chemical, biologic or physical -- to impact human health, it must somehow enter the body. The four main media or substances that carry agents into the body are air, water, soil, and food. Also, the man-made or “built” environment – industries, houses, and automobiles – provides new ways for people to become exposed to environmental agents.
In addition to the oxygen we need to survive, the air we breathe carries a number of tiny particles, invisible to the naked eye, that are able to enter our airways and travel deep into our lungs. Some of these particles can increase disease risk, including fine particulate matter (PM 2.5), sulfur dioxide, nitrogen dioxide, ozone, and radon. Air pollution occurs both indoors and outdoors. In fact, concentrations of pollutants indoors can be two to five times as high as the outdoor concentration. Adequate intake of water is necessary to sustain life. Water, like air, includes many microscopic particles. Microorganisms – bacteria, protozoa, and viruses -- and chemicals exist in our water supplies. Before the creation of sanitation systems to clean water, disease and death from water-borne illnesses, such as cholera (a bacterial infection that can be deadly), were quite common. Today, the government requires public water suppliers to use disinfection systems and monitor water quality. These systems rid the water of many microorganisms and have been successful in decreasing the number of people contracting water-borne illnesses. Despite these efforts, certain microorganisms and chemicals still are found in our water. Also, people who get their drinking water from private wells do not have to follow the same rules as public water suppliers. Their water still may contain chemicals or microorganisms. The primary uses of water through which individuals may be exposed to chemicals and microorganisms include drinking, cooking, and bathing. In the same way that air and water can contain toxins, soil also may contain hazardous substances. Radon, a known carcinogen or cancer-causing substance, is a naturally occurring gas that leaches out of rocky soil and into homes, causing indoor air pollution. Toxic substances dumped at hazardous waste sites can corrode their containers, spilling their contents into the surrounding ground. Soil often contains pesticides used either commercially or at private residences. These toxins then may be ingested or absorbed when people eat crops grown in contaminated soil or walk or play on contaminated ground. In this fashion, soil can allow potentially toxic substances to enter into the human body.
In addition to air and water, a third requirement for life is food. We cannot live without nourishment, and food provides yet another route for toxins to enter the body. Infectious microorganisms, such as salmonella, cause food-borne illnesses. Chemicals such as pesticide residues on fruits and vegetables can be ingested along with food. Also, research has shown that dietary habits, such as intake of saturated fats, cholesterol, fiber, and fruits and vegetables, have a direct effect on human health. |




